Title | Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Kim SHyun, Joseph RM, Frazier JA, O'Shea TM, Chawarska K, Allred EN, Leviton A, Kuban KK |
Corporate Authors | Extremely Low Gestational Age Newborn(ELGAN) Study Investigators |
Journal | J Pediatr |
Volume | 178 |
Pagination | 101-107.e2 |
Date Published | 2016 Nov |
ISSN | 1097-6833 |
Keywords | Autism Spectrum Disorder, Checklist, Child, Female, Humans, Infant, Extremely Premature, Infant, Newborn, Male, Mass Screening, Predictive Value of Tests, Reproducibility of Results, Sensitivity and Specificity, Surveys and Questionnaires |
Abstract | OBJECTIVE: To examine the predictive validity of the Modified Checklist for Autism in Toddlers (M-CHAT) administered at age 24 months for autism spectrum disorder (ASD) diagnosed at 10 years of age in a US cohort of 827 extremely low gestational age newborns (ELGANs) followed from birth. STUDY DESIGN: We examined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the M-CHAT in predicting an ASD diagnosis at age 10 years based on gold standard diagnostic instruments. We then assessed how these predictive parameters were affected by sensorimotor and cognitive impairments, socioeconomic status (SES), and emotional/behavioral dysregulation at age 2 years. RESULTS: Using standard criteria, the M-CHAT had a sensitivity of 52%, a specificity of 84%, a PPV of 20%, and an NPV of 96%. False-positive and false-negative rates were high among children with hearing and vision impairments. High false-positive rates also were associated with lower SES, motor and cognitive impairments, and emotional/behavioral dysregulation at age 2 years. CONCLUSIONS: Among extremely preterm children with ASD, almost one-half were not correctly screened by the M-CHAT at age 2 years. Sensorimotor and cognitive impairments, SES, and emotional/behavioral dysregulation contributed significantly to M-CHAT misclassifications. Clinicians are advised to consider these factors when screening very preterm toddlers for ASD. |
DOI | 10.1016/j.jpeds.2016.07.052 |
Alternate Journal | J. Pediatr. |
PubMed ID | 27592094 |
PubMed Central ID | PMC5165696 |
Grant List | UL1 TR001863 / TR / NCATS NIH HHS / United States M01 RR002172 / RR / NCRR NIH HHS / United States R03 MH092617 / MH / NIMH NIH HHS / United States R01 MH100182 / MH / NIMH NIH HHS / United States P30 HD018655 / HD / NICHD NIH HHS / United States U01 NS040069 / NS / NINDS NIH HHS / United States R01 MH087554 / MH / NIMH NIH HHS / United States |