Predictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm.

TitlePredictive Validity of the Modified Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm.
Publication TypeJournal Article
Year of Publication2016
AuthorsKim SHyun, Joseph RM, Frazier JA, O'Shea TM, Chawarska K, Allred EN, Leviton A, Kuban KK
Corporate AuthorsExtremely Low Gestational Age Newborn(ELGAN) Study Investigators
JournalJ Pediatr
Volume178
Pagination101-107.e2
Date Published2016 Nov
ISSN1097-6833
KeywordsAutism Spectrum Disorder, Checklist, Child, Female, Humans, Infant, Extremely Premature, Infant, Newborn, Male, Mass Screening, Predictive Value of Tests, Reproducibility of Results, Sensitivity and Specificity, Surveys and Questionnaires
Abstract

OBJECTIVE: To examine the predictive validity of the Modified Checklist for Autism in Toddlers (M-CHAT) administered at age 24 months for autism spectrum disorder (ASD) diagnosed at 10 years of age in a US cohort of 827 extremely low gestational age newborns (ELGANs) followed from birth.

STUDY DESIGN: We examined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the M-CHAT in predicting an ASD diagnosis at age 10 years based on gold standard diagnostic instruments. We then assessed how these predictive parameters were affected by sensorimotor and cognitive impairments, socioeconomic status (SES), and emotional/behavioral dysregulation at age 2 years.

RESULTS: Using standard criteria, the M-CHAT had a sensitivity of 52%, a specificity of 84%, a PPV of 20%, and an NPV of 96%. False-positive and false-negative rates were high among children with hearing and vision impairments. High false-positive rates also were associated with lower SES, motor and cognitive impairments, and emotional/behavioral dysregulation at age 2 years.

CONCLUSIONS: Among extremely preterm children with ASD, almost one-half were not correctly screened by the M-CHAT at age 2 years. Sensorimotor and cognitive impairments, SES, and emotional/behavioral dysregulation contributed significantly to M-CHAT misclassifications. Clinicians are advised to consider these factors when screening very preterm toddlers for ASD.

DOI10.1016/j.jpeds.2016.07.052
Alternate JournalJ. Pediatr.
PubMed ID27592094
PubMed Central IDPMC5165696
Grant ListUL1 TR001863 / TR / NCATS NIH HHS / United States
M01 RR002172 / RR / NCRR NIH HHS / United States
R03 MH092617 / MH / NIMH NIH HHS / United States
R01 MH100182 / MH / NIMH NIH HHS / United States
P30 HD018655 / HD / NICHD NIH HHS / United States
U01 NS040069 / NS / NINDS NIH HHS / United States
R01 MH087554 / MH / NIMH NIH HHS / United States